If you’re in perimenopause, you’ve probably noticed your skin changing. Wrinkles deepen, skin thins and collagen takes a nosedive. By age 50, women can lose up to 30% of their skin’s collagen due to declining estrogen levels. That’s a staggering number! That’s why I love evidenced-based skincare! Topical estriol and estradiol—two forms of estrogen—are amazing tools for restoring skin elasticity, hydration and even reducing wrinkles. 

How Estrogen Affects the Skin

When estrogen levels decline, skin becomes drier and less elastic. This makes the skin more prone to fine lines and sagging.  Estrogen plays a crucial role in maintaining skin health by influencing collagen production, hydration, and elasticity. The decline in estrogen during perimenopause accelerates skin aging, leading to atrophy, dryness, and wrinkles (Svoboda et al., 2018) (Lephart & Naftolin, 2021).

Collagen and Elastin Synthesis

Topical application of estradiol and estriol stimulates the synthesis of collagen I and III, as well as elastin, which are critical for maintaining skin firmness and elasticity (Feifei et al., 2024) (Lephart & Naftolin, 2022).

A 2019 study published in the Journal of Drugs in Dermatology found that topical estriol significantly increased skin elasticity and hydration after 12 weeks of consistent use. Another clinical trial reported up to a 30% improvement in skin thickness and firmness—all without systemic absorption concerns. 

The Bottom Line

Perimenopausal skin changes can be frustrating, but they’re not irreversible. Topical estriol and estradiol offer a science-backed way to restore lost collagen, improve hydration, and smooth out wrinkles. If your skincare routine isn’t cutting it anymore, this might be the missing link. A routine that combines SPF, a retinoid and targeted serums are always the foundation to healthy, glowing skin.